FRIABILITY TEST

(A) Subjective:  Procedure for performing Friability test on Tablets.
(B) Purpose: This procedure is applicable for friability test on tablets and calibration of friabilator used in pharmaceutical company.
(C) Name of the Apparatus: Friabilator.
(D) Significance of Friability Test: This test is intended to determine the Physical Strength of the Tablet.
(E) Description of Apparatus:
(a) Design of Friabilator:
Frialibility1
(b) Apparatus:

                     Specifications                                Description
Drum It is made up of Transparent Synthetic Polymer.
Diameter: 283- 291 mm
Depth: 36- 40 mm
Curved Projection Inner Radius: 75.5- 85.5 mm
It enables tumbling of tablets at each turn of Drum.
Drum Height                                  156 ± 2 mm
Or
6 inches
 Drum Rotation 25 ± 1 rpm

(F) Procedure of Friability Apparatus:
For tablet with an average weight of 0.65g or less; a sample of whole tablet correspond to 6.5g should be taken.
For tablet with an average weight of more than 0.65g; then take sample of 10 whole tablets.
Friability 2
Result: A maximum loss of weight not greater than 1% is acceptable.
Note: If size or shape of tablets causes irregular tumbling then adjust drum base so that it form an angle of about 10 degree with horizontal.
(G) Calibration of Friabilator:

             (a) Calibration of RPFriability 3

 

                (b) Calibration of timer

Friability 4

                                     (c) Calibration of Number of Counts

Friability 5
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